Amit and Joey’s paper published in MBoC!

Amit and Joey’s paper, “Multiple C2 domain–containing transmembrane proteins promote lipid droplet biogenesis and growth at specialized endoplasmic reticulum subdomains,” has been published in Molecular Biology of the Cell! We show that MCTP1 and MCTP2 localize to ER subdomains that are sites of lipid droplet (LD)  biogenesis. The MCTP reticulon homology domains promote membrane curvature and LD biogenesis, while the C2 domains bind charged lipids, promoting ER-LD contacts and LD growth. Intriguingly, MCTPs localize to multiple ER-organelle membrane contact sites, suggesting a role in co-ordination of multiple organelle interactions!